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Brain microvascular endothelial cells express five carriers for the amino acid alanine belonging to two groups, neutral amino acid transporters (ASCT/SLC1A) or small neutral amino acid transporters (SNAT/SLC38A)

doi: 10.1210/endo.136.2.7835306

However, reducing equivalents are needed as well, to activate the ER oxidase ERO1 (Kim et al., 2012) and to reduce disulfide isomerases so that they can catalyze reduction of improper disulfide bonds (Schwaller et al., 2003)

Lubkowska A, Szygu\la Z, Chlubek D, Banfi G (2011) The effect of prolonged whole-body cryostimulation treatment with different amounts of sessions on chosen pro-and anti-inflammatory cytokines levels in healthy men

These results indicated that tumors with high ACTL6A expression, which rely more heavily on GSH metabolism than those with low ACTL6A expression, are more sensitive to ferroptosis inducers or GCLC inhibitors