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nevertheless, data on AD seem controversial since a large study and a Mendelian randomization revealed a causal association between genetically elevated CRP and reduced risk for AD, while another study reported that genetically predicted increased CRP may be a causal risk for AD [578,579,580]

1-7 Published: June 1, 2025 1 School of Medicine, University of Miami Miller, Miami, FL 2 David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 3 Mohawk Valley Health System, Utica, NY 4 Sylvester Comprehensive Cancer Center, University of Miami Health System, Miami, FL 5 University of Texas MD Anderson Cancer Center, Houston, TX 6 Massachusetts General Hospital, Boston, MA 7 Cleveland Clinic, Taussig Cancer Institute, Cleveland, OH * Corresponding author: Stuart E

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The key differences lie in the application method and the area covered