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Patients at this age have also been reported to have a high prevalence of vitamin B 12 deficiency, with estimates of up to 20% in the elderly

Furthermore, AH neurons are characterized by having both an early and a late afterhyperpolarization and action potentials that are only partially blocked by TTX, consisting of currents carried by voltage-gated sodium and calcium channels

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Hence, ME/CFS significantly reduces a patients quality of life (11, 24, 2931), impacting activities of daily living, socialising, family life, emotional wellbeing, work, and education (11, 23)