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However, it is known that a randomized, controlled clinical trial is the prerequisite for evaluating the efficacy of a given treatment

[DOI] [PubMed] [Google Scholar] 135.Shep D, Khanwelkar C, Gade P, Karad S

14 Upon application to the skin, DHA undergoes a Maillard reaction: the carbonyl group of DHA reacts with amino acids such as arginine, histidine, and lysine in the stratum corneum to produce brown-black chromophores, known as melanoidins, which provide a brown coloration (Figure 2)

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