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Semaglutide was initiated at 0.25 mg per week for the first 4 weeks via a pre-filled pen injector, escalating in a fixed-dose regimen every 4 weeks to reach the maintenance dose of 2.4 mg by week 16 (lower maintenance doses were permitted if participants were unable to tolerate 2.4 mg) (Extended Data Fig
This selectivity makes the peptide an ideal tool for studying fat metabolism in isolation from other growth hormone effects
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Cell Metabolism , 31(3), 529544
It does not bind the GH receptor or elevate IGF-1 levels
