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Xanthine oxidase is mainly expressed in the endothelium and can be activated by ATII

Nedder M, Boland S, Devineau S, Zerrad-Saadi A, Rogozarski J, Lai-Kuen R, et al
constructed a model of chronic pancreatitis using Adam17ex/ex mice (which are homozygous Adam17ex alleles that result in a significant decrease in ADAM17 expression) and their wild-type (WT) homogeneous mice

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