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1D228 targets TRK signaling and produced synergistic effect in tumor suppression The RNA-sep results showed that 1D228 downregulated a variety of oncogenes, so to further verify whether 1D228 also acts on other targets, we analyzed the inhibition rate of compound 1D228 against 77 TK kinases at a concentration of 500 nM using the HTRF kinase assay (Fig
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These findings indicate a crucial role of CREM in post-meiotic germ cells differentiation, linking the action of hormonal stimuli to direct regulation of spermatogenesis genes (14)
doi: 10.1016/j.neubiorev.2021.10.005 33 ShelefL
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