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Low energy can also be caused by other factors, such as poor sleep, stress, thyroid concerns, anemia, nutritional deficiencies, or underlying health conditions

It is a synthetic peptide modelled on residues 176191 of the C-terminal end of human growth hormone, modified by adding a tyrosine residue to the N-terminus to improve stability

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While efficacy endpoints for weight loss in those trials were modest, the compound exhibited a favorable safety profile, supporting its later GRAS designation for food use