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Previous reports suggest that B 12 deficiency-associated dysfunction of methionine synthase reduces the availability of methionine and subsequently S-adenosyl-methionine, which is an important methyl group donor (Figure 2)
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ADH1C exhibits high activity for ethanol oxidation to acetaldehyde, therefore, having a significant role in ethanol catabolism [3]
However, these agents also affect normal healthy cells and induce various side effects, such as nausea, dizziness, fatigue, somnolence and insomnia
