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Nature 484(7394):333338 Hiraizumi M, Akashi T, Murasaki K, Kishida H, Kumanomidou T, Torimoto N, Nureki O, Miyaguchi I (2024) Transport and inhibition mechanism of the human SGLT2MAP17 glucose transporter

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However, persistent inflammation and oxidative stress can compromise the integrity of this barrier, particularly affecting the tight junction proteins such as ZO-1 and occludin, which are essential for maintaining the structural and functional integrity of the BTB (65)

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