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Water without a buffer will cause pH to dramatically change so pH and TA must work together to find a balance

Despite conservation of the core fold among SLC6 transporters, subtype-specific structural features confer distinct functional profiles

Formulations should incorporate stabilizing technologies (such as ethosomes or encapsulation systems) to reduce irritation potential while enhancing permeation without overwhelming the skin barrier

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Tetrahydrocannabinol induces brain mitochondrial respiratory chain dysfunction and increases oxidative stress: a potential mechanism involved in cannabis-related stroke