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Selectivity of NNMT inhibitors Test compounds were screened in biochemical assays for activity against three structurally similar methyltransferases, including catechol-O-methyltransferase (COMT), DNA (cytosine-5)-methyltransferase 1 (DNMT1), and protein arginine methyltransferase 3 (PRMT3)

By maintaining mitochondrial homeostasis and reducing oxidative stress, 2-APQC emerges as a potential candidate for treating heart failure and related cardiac conditions 188

Those conditions relate to pancreas and kidney

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