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Interestingly, it is worth noticing that BBB as a carrier is extremely pivotal since glucose (also called fuel for the brain) transportation is vital for the appropriate functioning of the human brain and around 20% of the total body energy is used by the brain to work effectively [3, 6]

Additionally, experimental models, including animal studies for various diseases, have provided insights into its multifaceted pharmacological properties (Table 1)

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Hancock BG, Black CD

Scientists approach the study of carbolines in coffee cautiously, due to their strong biological actions on the nervous system and coffee being a rich dietary source