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Unlike full-length erythropoietin, ARA-290: Does not bind the classical erythropoietin receptor responsible for red blood cell production Does not increase hematocrit Does not stimulate bone marrow erythropoiesis Instead, it selectively activates anti-inflammatory and cytoprotective pathways

The 2024 NICE guideline on B12 deficiency in over-16s is built around identifying and treating the cause, not just topping up the number

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Oximes and hydrazones in bioconjugation: mechanism and catalysis
