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When sustained, LEA may progress to relative energy deficiency in sport (REDs), a broader syndrome involving disruptions in metabolic rate, menstrual function, immune response, bone health, and cardiovascular physiology [89]
A tenfold cross-validation was used for internal validation and to obtain 95% CIs for the AUC
Mesecke et al , 2005
They have been found to inhibit the expression of proapoptotic proteins (Bax and Caspase-3), increase the level of antiapoptotic protein (Bcl-2), reduce the level of MDA, and improve the activities of SOD and GSH (e.g., CoQ10) [236]
However, in these complex chronic illnesses, this inflammatory response fails to shut off, leading to a prolonged overproduction of pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-)
