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The 143-3 protein is involved in various physiological processes, including signal transduction, cell proliferation, apoptosis, autophagy, cell cycle regulation, repolarization of cardiac action, cardiac development, intracellular electrolyte homeostasis, neurodevelopment, and innate immunity

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For subsequent experiments, 10 nM (first dose to decrease viability), 1 nM (highest dose not affecting viability), and 0.1 nM (dose before 1 nM) were selected

Oxidation or certain chemical modifications of cysteinyl sulfur significantly affect Zn(II) binding to cysteine residues and the overall zinc-binding site in the protein

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