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Efforts are ongoing to develop synthetic derivatives of scopoletin and to characterize and improve its bioavailability and pharmacokinetic properties (96)

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We discovered SnCE1 having an autoacetyltransferase (AcT) activity and confirmed earlier reports stating its weak DUB activity, cleaving Lys11-, Lys48- and Lys63-linked Ub chains but acting as an efficient deSUMOylase 26

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155157 One mechanism by which cholesterol likely drives these processes is through its role in determining the physical properties of the cell surface

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