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2017;58(3):e1058

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Elevation of ROS content in tumor cells can also be caused by a lack of regulation by tumor suppressors of the antioxidant enzyme genes

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Last but not least, the real-life ICU scenario in which patients with ALI/ARDS were treated with a combination of pharmacological and non-pharmacological interventions is difficult to replicate in mouse models, and endpoint assessment in experimental models does not accurately reflect the disease progression in human ALI/ARDS [154]