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The copper component is well-tolerated at recommended doses but should be monitored in long-term use

doi:10.1097/md.0000000000002895 Olsen LN, Fischer M, Evans PA, Gliemann L, Hellsten Y

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The documented mechanisms are: VEGF stimulation in dermal fibroblasts that supports the microvascular network feeding the follicle, collagen and glycosaminoglycan synthesis at the follicular basement membrane, anti-inflammatory signaling that calms the chronic micro-inflammation associated with androgenetic alopecia, and direct follicular signaling that extends the anagen growth phase