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Given the difficulty of targeting endothelial cells in the dermis, inhibiting downstream pathways activating melanocytes, like EDN-1/EDN receptor signaling [176,177,178,179], could be particularly relevant for treating melasma and solar lentigo as this signaling pathway is upregulated in these conditions [180]
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CRP is a marker of inflammatory disease
[PubMed 3970025] 992
Anesthesiology 132 , 11971211 (2020)
