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Recent studies have highlighted the role of mitochondrial impairment and altered energy metabolism as key contributors to the pathophysiology of GWS, with their severity correlating to disease progression in 19 veterans suffering from GWS and 17 healthy controls, comparing these factors to markers of peripheral inflammation (Golomb et al., 2023)

Chronically high glucocorticoid levels induce neuronal atrophy and inhibit neurogenesis and synaptic plasticity in the hippocampus and prefrontal cortex, whereas excess IL-1 reduces BDNF production, collectively contributing to a depressed mood [306308]

These self prescribed treatments are illegal and putting people at risk