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Moreover, low levels of GB, applied exogenously or generated by transgenes for the biosynthesis of compatible solutes can induce the expression of certain stress-responsive genes, including those for enzymes that scavenge reactive oxygen species [40]

In the endoplasmic reticulum (ER), oxidative protein folding through the ER oxidoreductin 1 (ERO1)- protein disulfide isomerase (PDI) axis continuously generates H 2 O 2 , which is locally contained and recycled by peroxiredoxin 4 (PRDX4) and the glutathione (GSH)/thioredoxin (Trx) system (Fig

Andrographolide treatment can reverse the death receptor-dependent apoptosis pathway and mitochondria-dependent apoptosis pathway in obese mice, inhibit myocardial collagen deposition, cardiomyocyte apoptosis and cardiac hypertrophy, and inhibit the expression of the inflammatory marker COX-2 while enhancing the IGF1R/PI3K/Akt signalling pathway associated with cell survival, which is a compensatory survival mechanism that may mitigate the deleterious effects induced by a high-fat diet ( It can be seen from the above that andrographolide also has a certain therapeutic effect on cardiovascular diseases, such as myocarditis, obesity, atherosclerosis and other diseases

Yuen MF, Heo J, Jang JW, Yoon JH, Kweon YO, Park SJ, Tami Y, You S, Yates P, Tao Y, Cremer J, Campbell F, Elston R, Theodore D, Paff M, Bennett CF, Kwoh TJ

The most common are mild irritation or bruising around the vein