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The curve expands upon the earlier P-F (Potential Failure to Functional Failure) curve, first introduced by Nowlan and Heap in 1978, by adding the "Design" and "Installation" phases

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The substance itself is not stored in the body, and the rate of its synthesis is proportional to the rate of its release into the bloodstream. MELATONIN SYNTHESIS In the body, melatonin synthesis occurs thanks to the action of its precursor, which is tryptophan taken from the blood

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