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162 NemtsovaY.SteinertB
2009 Oct;10(10):1105-16
The accurate framing is that NSI-189's "neurogenic" label rests on preclinical models plus a hippocampal-volume MRI marker not on a confirmed molecular target, and not on a demonstration that it increases neurogenesis in humans
Since IGFBPs normally sequester most circulating IGF-1, this escape from binding protein control creates much higher free (bioactive) concentrations at the injection site
Annals of the New York Academy of Sciences , 1194, 179-189
