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10.1002/anie.202500247 89 SongN.WangX.HaL.HuL.MeiS.LiangY.et al (2025b)

Decreased peak Vo2 can lead to the early onset of anaerobic metabolism and muscle fatigue

improves adipose insulin sensitivity, which may prevent ectopic fat deposition Benefits of Tirzepatide Reduced inflammation: Both medications are proven to reduce inflammation markers which leads to decreased inflammation response & oxidative stress

These supplements may well prevent your active folate falling too low to affect the methylation cycle
