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In mitochondria [edit] The metabolism of propionyl-CoA occurs in the mitochondria and requires Vitamin B 12 (as adenosylcobalamin) to make succinyl-CoA

It is widely studied in preclinical models for its role in cellular signaling, angiogenesis, and tissue-specific biological responses

For example, Ozempic is covered only to treat diabetes, and Wegovy is covered for the indication of Major Adverse Cardiovascular Events (MACE) reduction in overweight/obese adults, but neither are currently covered for obesity as a standalone condition

Methylcobalamin, while slightly less stable, remains safe and effective when handled properly in a clinical setting

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