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Similar content being viewed by others Introduction Antibiotics have been important in saving lives and enabling advances in modern medicine 1

For the timepoint study ( n = 50), male and female APOE-TR mice were euthanized at three different timepoint (10-, 25-, and 50-weeks) for three homozygous genotypes: APOE2-TR, APOE3-TR, and APOE4-TR (Supplementary Table S1)

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Red blood cells, haematocrit and haemoglobin showed a gradual decline following AIP induction but cannot be directly attributed to the surgical procedure, as three animals maintained stable haematological parameters in the initial 16 days but began to reduce haematocrit and haemoglobin levels weeks after surgery

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