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Apoptosis Apoptosis can be divided into caspase-dependent and caspase-independent

The cell viability was significantly increased upon co-delivery of BSO@MOF-L with ferroptosis inhibitors, such as ferrostatin-1, GSH, and vitamin E, which acted by radical-trapping or antioxidation (Fig

p62 itself is a transcriptional target of Nrf2, forming a positive feedback loop that enhances antioxidant defenses and autophagic capacity

[DOI] [PubMed] [Google Scholar] Zhao P., Wang Y., Kang X., Wu A., Yin W., Tang Y., Wang J., Zhang M., Duan Y., Huang Y

Its signal transduction is regulated by ROS, calcium ions, ATP, and lipid and protein homeostasis, playing crucial roles in transcription factor-driven gene expression