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Description
It has been reported that there is no reduction in its secretion in patients with T2DM [13] but a nearly total loss of insulinotropic effect is observed, even at supraphysiological concentrations, implying the existence of GIP resistance [14]

[DOI] [PMC free article] [PubMed] [Google Scholar] 103.Sekhar R.V., Patel S.G., Guthikonda A.P., Reid M., Balasubramanyam A., Taffet G.E., Jahoor F

These combination therapy studies were included in the NCCCC OA guideline 2008

[DOI] [PubMed] [Google Scholar] 120.Varatharajan R., Sattar M.Z., Chung I., Abdulla M.A., Kassim N.M., Abdullah N.A

However, these drugs have many adverse effects as these pathways are significant in healthy proliferating cells
