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In this review, we summarize and discuss the relationship between carnitine and NAFLD, effects of L-carnitine (the biologically active form of carnitine) supplementation in NAFLD, and related diseases, including non-alcoholic steatohepatitis (NASH), cirrhosis, hepatic cellular cancer (HCC), alcoholic fatty liver disease, and viral hepatitis

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The decrease in complex I activity drives an increase in glycolysis which in turn results in increased lactate production in intestinal epithelial cells and, in turn, increased Lac-Phe synthesis