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Indeed, this type of inhibitory mechanism was described for blocking the interaction between another cytokine receptor, the interleukin-2 receptor, and its ligand

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Webb AJ, Patel N, Loukogeorgakis S, Okorie M, et al

Besides 5-HT-1A receptors, 5-HT-2C receptors also showed their involvement in behavioral alteration, and it is reported that downregulation/desensitization of 5-HT-2C receptors (Liu et al