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Metformin treatment had a smaller and non-statistically significant effect in LC female PBMCs (Supplementary Figure S7B, CD4 p = 0.31, CD8 p = 0.42), where treatment reduced on average CD4 and CD8 T cell proliferation in female LC donors by 5.2% and 7.6% respectively

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NSCLC patients exhibit aberrant expression of DM-specific microbial dysbiosis markers (CRP, LBP, CD14), implicating microbiota-derived endotoxemia in lung carcinogenesis (Qian et al., 2022)

We recommend consulting with a healthcare professional to determine the appropriate Zinc-to-Copper ratio for your individual dietary needs
