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In addition, a retinal examination is suggested for all patients within six months of initiating treatment and periodically while continuing treatment

Cell 64 , 92104 (2016)

The condition is more prevalent in males and presents as insidious onset pain at the proximal insertion site of the quadriceps tendon over the patella (20% of cases), pain at the inferior pole of the patella (70% of cases), or less commonly, pain at the tibial tuberosity (10%), which may increase during physical activity and digital pressure [4,5,6]

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This copper peptide is found in the blood, saliva, and urine of mammals, including dogs, and plays a key role in tissue repair and anti-inflammatory processes