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The stated goal was to "civilize" Native Americans, Alaska Natives and Native Hawaiians, but that was often carried out through abusive practices

Typische Anzeichen sind schnelle Erschpfung, Muskelschwche oder Antriebslosigkeit

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These clinical manifestations are probably secondary to mitochondrial dysfunction in the heart and smooth muscle (particularly the gastrointestinal tract) and an autonomic nervous system insult (neurotransmitters)

Aprs une priode de moindre intrt, son importance biologique a t redcouverte en 1952, mettant en lumire son rle essentiel dans la croissance larvaire du Tenebrio molitor par le mtabolisme des rserves lipidiques