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The European Food Safety Authority (EFSA) identified a safe supplementation dosage of 20 mg per day, which is at least 250 times higher than the typical dietary intake, and established a No Observed Adverse Effect Level (NOAEL) of 100 mg/kg body mass per day [11,42]

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J Biochem 119 : 533540

These values calculate such that an average person will synthesize 2.4 mg of CRP/day, increasing up to 174 mg/day in response to an exacerbating event ( While synthesis and hepatic release rates of CRP in response to cytokine stimulation have been reported (41, 43, 56), measured increases in CRP blood level appear to involve a lag of 612 h after stimulation (40, 57, 58)