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doi: 10.1038/s41380-024-02428-5 424 ZhaoY.WuX.LiX.JiangL.-L.GuiX.LiuY.et al

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This is in line with the notion that the IVD is immune privileged due to its avascularity [30] and the expression of Fas ligand (FasL), which induces apoptosis of invading Fas-bearing T-cells [24, 31]

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In detail, ROS could activate TRPA1, via oxidizing cysteine residues ( 2+ influx (Shimizu et al., 2014)

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