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Intervention study While the studies cited above are largely consistent with the existence of a high-folatelow-vitamin B-12 interaction affecting both tHcy and MMA metabolism, data are limited on the effect of high-dose folic acid supplements on these 2 biomarkers in vitamin B-12deficient individuals
Oxidative stress is crucial to the development of podocyte damage, glomerular sclerosis, and proteinuria [38]
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