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Conclusion This review elucidated the significance of the metabolism-inflammation-oxidative stress axis in the occurrence and development of OA, and also dialectically discussed the mechanisms and clinical benefits of beneficial nutrients in the treatment of OA

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HIF-1 protein was increased approximately six times after irradiation of 41 @NP, but only 2.5x in the case of 41 &Me@NP

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Plant Cell 10 , 10551068 (1998)

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For example, glutamine enters cells through the SLC1A5 amino acid transporter and is converted into glutamate, catalyzed by the GLS enzyme

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