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Krmer M, Bongaerts J, Bovenberg R, Kremer S, Mller U, Orf S, Wubbolts M, Raeven L (2003) Metabolic engineering for microbial production of shikimic acid

Key finding: Reduced oxidative stress markers and inflammatory signaling in neuronal cells neuroprotection beyond skin and wound healing

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Simultaneously, the catalytic subunit of the polycomb repressive complex 2 (PRC2), enhancer of zeste homolog 2 (EZH2) facilitates trimethylation of histone lysine 27 (H3K27me3), which is mainly linked with transcriptional suppression of steroidogenic and survival-related genes during luteal regression (134)

General lifestyle changes such as controlling stress, adequate sleep, exercising, and avoiding alcohol may also play a role