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The Importance of Murine Models in Determining In Vivo Pharmacokinetics, Safety, and Efficacy in Antimalarial Drug Discovery

doi: 10.1053/j.gastro.2016.01.032 [DOI] [PMC free article] [PubMed] [Google Scholar] 48.Abul-Husn NS, Cheng X, Li AH, Xin Y, Schurmann C, Stevis P, et al

This study also shows an increase in reduced glutathione activity in the magnesium and insulin treated rats which also suggest a potentiating effect of magnesium and insulin on reduced glutathione production in these treatment groups

For peptide researchers working with doses of 100 to 500 mcg, where the injection volume might be 0.04 to 0.2 mL, this accuracy difference is not trivial