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Description
This diversity complicates the development of broad-spectrum senomorphic therapies.31 Senomorphic compounds that work effectively in one tissue might not produce the same results in others, requiring tailored or tissue-specific therapies.199 Regulatory Hurdles: Senomorphic therapies, particularly those derived from natural compounds (eg, resveratrol, curcumin), may face challenges in regulatory approval
These concepts have influenced the manner in which new technologies are evaluated in clinical trials, where conditions most conducive to a successful therapy (i.e., green knees) are selected for initial trials in humans
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[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Chang C.H., Tsai W.C., Lin M.S., Hsu Y.H., Pang J.H
