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Cholesterol regulation of hepatic HMG-CoA reductase
doi: 10.1053/j.gastro.2008.01.073

Hypertension pharmacogenomics: in search of personalized treatment approaches

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In a randomized placebo-controlled trial, metformin treatment was associated with a mean decrease in vitamin B 12 concentration by 19% and an increase in homocysteine concentration by 5% [52]