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Two doses of edaravone were selected to evaluate if the anti-oxidant exert a dose-dependent effect

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This research has implications for understanding the regulation of NAD+-dependent processes in cells

With respect to desensitization, all those data support the idea that agonists are able to promote a different regulation of OR as demonstrated for other GPCR such as the histamine H2 receptors (Alonso et al., 2014)