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Prediction of primary non-response to methotrexate therapy using demographic, clinical and psychosocial variables: results from the UK Rheumatoid Arthritis Medication Study (RAMS)

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Thus, the study provided evidence that the activation of SIRT1 can effectively suppress the cleavage of caspase-1 and the subsequent release of IL-1 caused by the NLRP3 inflammasome

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