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Nevertheless, the plateau for selenoprotein P in serum/plasma is achieved at higher levels, i.e., at Se intake of 6070 g/day and plasma Se levels of 90130 g/L (45, 51, 233)

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Notably, metabolites resulting from oxidative stress and oxidation/reduction reactions, such as monohydroperoxi polyunsaturated fatty acids and oxylipins, specifically epoxyeicosatrienoic acids (EETs) and the corresponding dihydroxy derivatives (DHET), were significantly enriched in the AC-like model, in line with the transcriptional programs identified based on scRNA-seq (Fig

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