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Patients often show serum concentrations toward the upper normal range in association with hypercalciuria [108]

Spagnolo P, Kropski JA, Jones MG, Lee JS, Rossi G, Karampitsakos T, et al

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70 The European Medicines Agencys Pharmacovigilance Risk Assessment committee recommended risk minimization measures (RMM) for flupirtine (use only after other analgesics were trialled, patients restricted to up to two week-long treatments, with weekly LFT) due to concern of rare serious liver injury associated with long-term use of flupirtine