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With age, GSH levels decrease by up to 50% compared to young subjects, contributing to increased oxidative stress and chronic low-grade inflammation (inflammaging). In the anti-ageing field, GSH IV acts on three main levels: direct neutralisation of free radicals and protection of dermal collagen, modulation of inflammation through NF-B inhibition, and reduction of melanogenesis through tyrosinase inhibition with clinically observable effects on skin tone and luminosity. The most robust clinical evidence concerns neuroprotection (improvement of motor symptoms in Parkinson's disease) and protection from chemotherapy-induced neuropathy

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Antioxidants 10(7):1111 Nakutis FS, Nishitokukado I, Dos Santos FM, Ortiz-Agostinho CL, de Alencar DT, Achtschin CG, Nunes VS, Leite AZ (2023) Sipahi AM (2023) evaluation of oxidative stress in an experimental model of crohns disease treated with hyperbaric oxygen therapy