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C.GleadleJ
The mechanisms driving central sensitization include elevated substance P, reduced descending pain inhibition, altered glutamate signaling, and microglial activation in the central nervous system
The TIRAP/MyD88-induced signaling cascade begins from the plasma membrane, and TRAM/TRIF from the endosomes (Kagan et al., 2008)
Methylcobalamin also promotes the formation of phosphatidylcholine (lecithin), an important component in myelin sheaths
But if you dont have enough B12, those processes slow down and you feel tired and exhausted
