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During this time, peroxynitritea reaction product between the superoxide radical and nitric oxidewas discovered in biological systems
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Finally, some drugs or natural compounds have been reported to have antitumor properties by targeting metabolic vulnerabilities such as alterations in glycolysis, OXPHOS, and glutamine metabolism [13]
Trends Pharmacol Sci 23:299302 Mosharov E, Cranford MR, Banerjee R (2000) The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes
