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Interestingly, Bacterial peptidoglycan has been found in atherosclerotic plaques, and increased expression of genes involved in its synthesis has also been reported in these patients [68]

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Selective impairment of this carrier-mediated transport can contribute to selective vulnerability of tissues to specific toxins: for example, chronically ethanol-fed hepatocytes become selectively depleted of mitochondrial glutathione because of defective carrier-mediated transport, which makes the hepatocytes susceptible to damage by reactive oxygen species generated from the oxidative metabolism of ethanol (22)

"It's a devastating disease," he said

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